Please use this identifier to cite or link to this item: http://hdl.handle.net/10070/302362
Note: the high definition versions of some images are not available online, but may be Ordered
Full metadata record
DC FieldValueLanguage
dc.contributor.authorBarr, Elizabeth L M-
dc.contributor.authorBarzi, Federica-
dc.contributor.authorHughes, Jaquelyne T-
dc.contributor.authorJerums, George-
dc.contributor.authorHoy, Wendy E-
dc.contributor.authorO'Dea, Kerin-
dc.contributor.authorJones, Graham R D-
dc.contributor.authorLawton, Paul D-
dc.contributor.authorBrown, Alex D H-
dc.contributor.authorThomas, Mark-
dc.contributor.authorEkinci, Elif I-
dc.contributor.authorSinha, Ashim-
dc.contributor.authorCass, Alan-
dc.contributor.authorMacIsaac, Richard J-
dc.contributor.authorMaple-Brown, Louise J-
dc.date2018-
dc.date.accessioned2018-05-15T23:00:27Z-
dc.date.accessioned2018-10-04T22:12:30Z-
dc.date.available2018-05-15T23:00:27Z-
dc.date.available2018-10-04T22:12:30Z-
dc.date.issued2018-04-
dc.identifier.citationDiabetes care 2018-04; 41(4): 739-747-
dc.identifier.urihttp://hdl.handle.net/10070/302362-
dc.description.abstractTo examine the association between soluble tumor necrosis factor receptor 1 (sTNFR1) levels and kidney disease progression in Indigenous Australians at high risk of kidney disease. This longitudinal observational study examined participants aged ≥18 years recruited from >20 sites across diabetes and/or kidney function strata. Baseline measures included sTNFR1, serum creatinine, urine albumin-to-creatinine ratio (uACR), HbA1c, C-reactive protein (CRP), waist-to-hip ratio, systolic blood pressure, and medical history. Linear regression was used to estimate annual change in estimated glomerular filtration rate (eGFR) for increasing sTNFR1, and Cox proportional hazards were used to estimate the hazard ratio (HR) and 95% CI for developing a combined renal outcome (first of a ≥30% decline in eGFR with a follow-up eGFR <60 mL/min/1.73 m2, progression to renal replacement therapy, or renal death) for increasing sTNFR1. Over a median of 3 years, participants with diabetes (n = 194) in the highest compared with the lowest quartile of sTNFR1 experienced significantly greater eGFR decline (-4.22 mL/min/1.73 m2/year [95% CI -7.06 to -1.38]; P = 0.004), independent of baseline age, sex, eGFR, and uACR. The adjusted HR (95% CI) for participants with diabetes per doubling of sTNFR1 for the combined renal outcome (n = 32) was 3.8 (1.1-12.8; P = 0.03). No association between sTNFR1 and either renal outcome was observed for those without diabetes (n = 259). sTNFR1 is associated with greater kidney disease progression independent of albuminuria and eGFR in Indigenous Australians with diabetes. Further research is required to assess whether TNFR1 operates independently of other metabolic factors associated with kidney disease progression.-
dc.language.isoeng-
dc.titleHigh Baseline Levels of Tumor Necrosis Factor Receptor 1 Are Associated With Progression of Kidney Disease in Indigenous Australians With Diabetes: The eGFR Follow-up Study.-
dc.typeJournal Article-
dc.relation.incollectionDept of Health Digital Library
dc.relation.incommunityE-Books
dc.view.styleebooks
dc.date.discovery2018en
dc.identifier.journaltitleDiabetes care-
dc.identifier.doi10.2337/dc17-1919-
dc.identifier.pubmedidhttps://ezpdhcs.nt.gov.au/login?url=https://www.ncbi.nlm.nih.gov/pubmed/29367427-
dc.identifier.affiliationMenzies School of Health Research, Darwin, Northern Territory, Australia elizabeth.barr@menzies.edu.au.. Baker Heart and Diabetes Institute, Melbourne, Victoria, Australia..-
dc.identifier.affiliationMenzies School of Health Research, Darwin, Northern Territory, Australia..-
dc.identifier.affiliationMenzies School of Health Research, Darwin, Northern Territory, Australia.. Royal Darwin Hospital, Darwin, Northern Territory, Australia..-
dc.identifier.affiliationDepartment of Endocrinology, Austin Health, Melbourne, Victoria, Australia.. Department of Medicine, University of Melbourne, Melbourne, Victoria, Australia..-
dc.identifier.affiliationThe University of Queensland, Brisbane, Queensland, Australia..-
dc.identifier.affiliationMenzies School of Health Research, Darwin, Northern Territory, Australia.. Nutrition and Population Health, University of South Australia, Adelaide, South Australia, Australia..-
dc.identifier.affiliationSydPath, St Vincent's Hospital Sydney, Sydney, New South Wales, Australia.. Faculty of Medicine, University of New South Wales, Sydney, New South Wales, Australia..-
dc.identifier.affiliationMenzies School of Health Research, Darwin, Northern Territory, Australia..-
dc.identifier.affiliationAboriginal Health, Sansom Institute for Health Research, University of South Australia, Adelaide, South Australia, Australia.. Indigenous Health, South Australian Health and Medical Research Institute, Adelaide, South Australia, Australia..-
dc.identifier.affiliationRoyal Perth Hospital, Perth, Western Australia, Australia..-
dc.identifier.affiliationMenzies School of Health Research, Darwin, Northern Territory, Australia.. Department of Endocrinology, Austin Health, Melbourne, Victoria, Australia.. Department of Medicine, University of Melbourne, Melbourne, Victoria, Australia..-
dc.identifier.affiliationDiabetes and Endocrinology, Cairns Base Hospital, Cairns, Queensland, Australia..-
dc.identifier.affiliationMenzies School of Health Research, Darwin, Northern Territory, Australia..-
dc.identifier.affiliationDepartment of Medicine, University of Melbourne, Melbourne, Victoria, Australia.. Department of Endocrinology and Diabetes, St Vincent's Hospital Melbourne, Melbourne, Victoria, Australia..-
dc.identifier.affiliationMenzies School of Health Research, Darwin, Northern Territory, Australia.. Royal Darwin Hospital, Darwin, Northern Territory, Australia..-
dc.identifier.pubmedurihttps://ezpdhcs.nt.gov.au/login?url=https://www.ncbi.nlm.nih.gov/pubmed/29367427-
dc.identifier.orcidhttp://orcid.org/0000-0003-4284-1716-
dc.identifier.orcidhttp://orcid.org/0000-0003-2372-395X-
dc.identifier.orcidhttp://orcid.org/0000-0001-8058-6977-
Appears in Collections:Dept of Health Digital Library

Files in This Item:
There are no files associated with this item.
Show simple item record


Items in Territory Stories are protected by copyright, with all rights reserved, unless otherwise indicated.